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Genomic analysis of Neurodegenerative Disease.

John Hardy1,*

1UCL Institute of Neurology, UCL, London, United Kingdom

In my talk, I will discuss how, because of the development of whole genome arrays and sequencing technologies, we are now able to find any type of genetic risk for neurodegenerative disease: Mendelian disease, through positional cloning and sequencing, rare, high risk variants through exome sequencing and burden analysis and common low risk variants through genome wide association analysis.  I will outline how whole genome expression analysis increases the power and resolution of genetic analysis and how we are now finding that genes for clinical syndromes often map to common biological pathways.

Keywords: Brain, DNA, Genomics