Bloodhound Technology™ - Returning to the roots of Hematology
Ann-Britt Lennartsson1, Mark Fellmann1,*
1Core Lab & Critical Care, Roche Diagnostics, Bromma, Sweden
Introduction: Bloodhound Technology™ enables the first fully integrated hematology analysis, combining Differential analysis, slide making & staining and digital morphology analysis on a very compact footprint. The technology combines proprietary image capture and pattern recognition algorithm to enumerate, identify, isolate and categorize red blood cells, platelets, white blood cells and reticulocytes in a seamless process.
Objectives: Every analysis and cell differentiation of the patient samples is based on the morphology assessment of the blood cells from a Romanowsky stained microscopy slide. The analyzer (cobas m 511) uses the Bloodhound Technology™ to print a precise volume of whole blood in a monolayer across a glass slide, followed by automated and controlled modified Romanowsky staining process and digital image processing to capture all required data for the analysis of the CBC and WBC differential. By using automated processes, the systems ensures high quality results across samples independent of the operator, providing comparable results throughout a patient history record.
Methods: Cells are identified and classified by more than 100 parameters regarding their morphology, making sure no detail is missed in the diagnosis of pathological samples. This enables the operator to focus on the pathological cells of interest and there is no need to look at the non-pathological cells. From here on, RBC can be sorted and reviewed according to their size, morphology and hemoglobin content all based on their presented morphology on the microscopy glass slide.
Results: Overall, Bloodhound Technology™ will establish a totally new and innovative way of processing hematology samples, taking us back to the roots of hematology: Differentiating cells based on their morphology. This will enable laboratories to improve their workflow, while focusing on samples that require special attention, improve diagnose and allocate precious staff time to samples where it really matters.
Conclusion: Returning to the roots of Hematology
Keywords: Blood, Method